IT1235013B - 1,4-diidropiridine, loro procedimento di preparazione e loro applicazione come medicamenti - Google Patents
1,4-diidropiridine, loro procedimento di preparazione e loro applicazione come medicamentiInfo
- Publication number
- IT1235013B IT1235013B IT8848259A IT4825988A IT1235013B IT 1235013 B IT1235013 B IT 1235013B IT 8848259 A IT8848259 A IT 8848259A IT 4825988 A IT4825988 A IT 4825988A IT 1235013 B IT1235013 B IT 1235013B
- Authority
- IT
- Italy
- Prior art keywords
- methyl
- methylene
- oxy phenyl
- substd
- opt
- Prior art date
Links
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 title 1
- -1 and R3 = H Chemical group 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 abstract 1
- 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP87401799A EP0302980B1 (fr) | 1987-08-03 | 1987-08-03 | 1,4-Dihydropyridines, leur procédé de préparation et leur application comme médicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8848259A0 IT8848259A0 (it) | 1988-08-02 |
| IT1235013B true IT1235013B (it) | 1992-06-16 |
Family
ID=8198243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT8848259A IT1235013B (it) | 1987-08-03 | 1988-08-02 | 1,4-diidropiridine, loro procedimento di preparazione e loro applicazione come medicamenti |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US4952592A (en]) |
| EP (1) | EP0302980B1 (en]) |
| JP (1) | JPH0733383B2 (en]) |
| KR (1) | KR960001724B1 (en]) |
| CN (1) | CN1038587C (en]) |
| AT (1) | ATE61588T1 (en]) |
| BE (1) | BE1001055A4 (en]) |
| CA (2) | CA1306261C (en]) |
| CH (1) | CH675999A5 (en]) |
| CZ (1) | CZ282077B6 (en]) |
| DD (1) | DD282008A5 (en]) |
| DE (2) | DE3768658D1 (en]) |
| DK (1) | DK430288A (en]) |
| ES (1) | ES2007543A6 (en]) |
| FI (1) | FI91406C (en]) |
| GB (1) | GB2208861B (en]) |
| GR (2) | GR880100507A (en]) |
| HU (1) | HU204523B (en]) |
| IE (1) | IE60358B1 (en]) |
| IL (1) | IL87321A (en]) |
| IN (1) | IN167550B (en]) |
| IS (1) | IS1549B (en]) |
| IT (1) | IT1235013B (en]) |
| LU (1) | LU87297A1 (en]) |
| MA (1) | MA21344A1 (en]) |
| NO (1) | NO170934C (en]) |
| NZ (1) | NZ225661A (en]) |
| PH (1) | PH25645A (en]) |
| PT (1) | PT88173B (en]) |
| RU (1) | RU2036922C1 (en]) |
| SK (1) | SK541388A3 (en]) |
| TN (1) | TNSN88081A1 (en]) |
| YU (1) | YU46547B (en]) |
| ZA (1) | ZA885684B (en]) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5242933A (en) * | 1990-07-10 | 1993-09-07 | Adir Et Compagnie | Piperidine, tetrahydropyridine and pyrrolidine compounds |
| ES2166462T3 (es) * | 1995-08-02 | 2002-04-16 | Smithkline Beecham Corp | Antagonistas del receptor de la endotelina. |
| RU2168987C2 (ru) * | 1997-04-15 | 2001-06-20 | Санкт-Петербургская Государственная Химико-Фармацевтическая Академия | Гипотензивное средство |
| RU2155036C2 (ru) * | 1998-11-11 | 2000-08-27 | Азад Зияд Оглы Абышев | Средство для лечения ишемической болезни сердца |
| IT1304513B1 (it) * | 1998-12-30 | 2001-03-19 | Endura Spa | Processo per la sintesi di 5-(alfa-idrossialchil)benzo(1,3)diossoli. |
| IL152021A0 (en) * | 2000-04-11 | 2003-04-10 | Sankyo Co | Pharmaceutical compositions containing pyridine derivatives |
| RU2187303C2 (ru) * | 2000-10-12 | 2002-08-20 | Азад Зияд Оглы Абышев | Способ получения таблеток диуманкала - forte по 0,01 г |
| DE60336485D1 (de) | 2002-08-19 | 2011-05-05 | Pfizer | Kombinationstherapie gegen hyperproliferative erkrankungen |
| RU2007106714A (ru) * | 2004-07-26 | 2008-09-10 | Байер Шеринг Фарма Аг (De) | Лечение легочной гипертензии путем ингаляции илопростата с препаратом микрочастиц |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| EP2351569B1 (en) | 2005-10-26 | 2012-08-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
| ATE551059T1 (de) | 2005-10-26 | 2012-04-15 | Asahi Kasei Pharma Corp | Fasudil in kombination mit bosentan zur behandlung von pulmonaler arterieller hypertonie |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| TW200736245A (en) * | 2005-11-29 | 2007-10-01 | Sankyo Co | Acid addition salts of optically active dihydropyridine derivatives |
| TW200806648A (en) * | 2005-11-29 | 2008-02-01 | Sankyo Co | Acid addition salts of dihydropyridine derivatives |
| US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
| WO2008070496A2 (en) | 2006-12-01 | 2008-06-12 | Bristol-Myers Squibb Company | N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
| WO2012037665A1 (en) | 2010-09-24 | 2012-03-29 | Oral Delivery Technology Ltd. | Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions |
| AU2014255381A1 (en) | 2013-04-17 | 2015-10-08 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| CN113574055B (zh) | 2019-01-18 | 2024-07-23 | 阿斯利康(瑞典)有限公司 | Pcsk9抑制剂及其使用方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3441648A (en) * | 1967-02-07 | 1969-04-29 | Smithkline Corp | Compositions and methods for lowering blood pressure with 1,4-dihydropyridines |
| US4031104A (en) * | 1972-04-18 | 1977-06-21 | Bayer Aktiengesellschaft | 1,4-Dihydropyridine carboxylic acid esters |
| JPS5978186A (ja) * | 1982-10-27 | 1984-05-04 | Yoshitomi Pharmaceut Ind Ltd | １，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体 |
| IE57810B1 (en) * | 1984-03-27 | 1993-04-21 | Delagrange Lab | 1,4-dihydropyridine derivatives,their preparation and their use |
| ES8507495A1 (es) * | 1984-03-27 | 1985-09-01 | Inst Investigacion Desarrollo | Un procedimiento para la preparacion de nuevas 1,4-dihidropirinas-4-(polioxialquilfenil)-sustituidas |
| JPH068294B2 (ja) * | 1985-02-26 | 1994-02-02 | 富山化学工業株式会社 | 新規な１，４−ジヒドロピリジン誘導体およびその塩 |
| EP0174131A3 (en) * | 1984-09-01 | 1989-06-07 | FISONS plc | Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them |
| JPH01207267A (ja) * | 1987-03-05 | 1989-08-21 | Yamanouchi Pharmaceut Co Ltd | ピリジン誘導体及び該化合物を含有する肝疾患治療剤 |
-
1987
- 1987-08-03 DE DE8787401799T patent/DE3768658D1/de not_active Expired - Lifetime
- 1987-08-03 EP EP87401799A patent/EP0302980B1/fr not_active Expired - Lifetime
- 1987-08-03 AT AT87401799T patent/ATE61588T1/de active
-
1988
- 1988-07-27 LU LU87297A patent/LU87297A1/fr unknown
- 1988-07-29 YU YU147088A patent/YU46547B/sh unknown
- 1988-07-29 CA CA000573422A patent/CA1306261C/fr not_active Expired - Lifetime
- 1988-07-29 DE DE3825962A patent/DE3825962A1/de not_active Withdrawn
- 1988-08-01 FI FI883603A patent/FI91406C/fi not_active IP Right Cessation
- 1988-08-01 DD DD88318537A patent/DD282008A5/de not_active IP Right Cessation
- 1988-08-01 MA MA21587A patent/MA21344A1/fr unknown
- 1988-08-01 NO NO883406A patent/NO170934C/no unknown
- 1988-08-01 JP JP63192591A patent/JPH0733383B2/ja not_active Expired - Lifetime
- 1988-08-02 IT IT8848259A patent/IT1235013B/it active
- 1988-08-02 DK DK430288A patent/DK430288A/da not_active Application Discontinuation
- 1988-08-02 ES ES8802413A patent/ES2007543A6/es not_active Expired
- 1988-08-02 IL IL87321A patent/IL87321A/xx not_active IP Right Cessation
- 1988-08-02 US US07/227,373 patent/US4952592A/en not_active Expired - Fee Related
- 1988-08-02 CZ CS885413A patent/CZ282077B6/cs not_active IP Right Cessation
- 1988-08-02 IE IE236488A patent/IE60358B1/en not_active IP Right Cessation
- 1988-08-02 TN TNTNSN88081A patent/TNSN88081A1/fr unknown
- 1988-08-02 PT PT88173A patent/PT88173B/pt not_active IP Right Cessation
- 1988-08-02 IS IS3378A patent/IS1549B/is unknown
- 1988-08-02 CH CH2922/88A patent/CH675999A5/fr not_active IP Right Cessation
- 1988-08-02 GR GR880100507A patent/GR880100507A/el unknown
- 1988-08-02 SK SK5413-88A patent/SK541388A3/sk unknown
- 1988-08-02 HU HU884065A patent/HU204523B/hu not_active IP Right Cessation
- 1988-08-02 BE BE8800893A patent/BE1001055A4/fr not_active IP Right Cessation
- 1988-08-02 GB GB8818356A patent/GB2208861B/en not_active Expired - Lifetime
- 1988-08-02 NZ NZ225661A patent/NZ225661A/xx unknown
- 1988-08-02 CN CN88106537A patent/CN1038587C/zh not_active Expired - Fee Related
- 1988-08-02 KR KR1019880009867A patent/KR960001724B1/ko not_active Expired - Fee Related
- 1988-08-03 IN IN556/MAS/88A patent/IN167550B/en unknown
- 1988-08-03 PH PH37337A patent/PH25645A/en unknown
- 1988-08-03 ZA ZA885684A patent/ZA885684B/xx unknown
-
1990
- 1990-08-28 CA CA000615848A patent/CA1306262C/fr not_active Expired - Lifetime
-
1991
- 1991-05-22 GR GR91400660T patent/GR3001984T3/el unknown
-
1992
- 1992-03-31 RU SU925011204A patent/RU2036922C1/ru active
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